Progesterone treatment increases Fos-immunoreactivity within some progestin receptor-containing neurons in localized regions of female rat forebrain
Identifieur interne : 000F83 ( Main/Exploration ); précédent : 000F82; suivant : 000F84Progesterone treatment increases Fos-immunoreactivity within some progestin receptor-containing neurons in localized regions of female rat forebrain
Auteurs : Anthony P. Auger [États-Unis] ; Jeffrey D. Blaustein [États-Unis]Source :
- Brain Research [ 0006-8993 ] ; 1996.
English descriptors
Abstract
In female rats, the sequential release of estradiol and progesterone from the ovaries is required for the expression of sexual behavior during the estrous cycle. Many of the neuronal effects of estradiol and progesterone involve estrogen and progestin receptors. Treatment with a behaviorally-effective dose of estradiol increases Fos expression, suggestive of neuronal response, and subsequent treatment with a behaviorally-effective dose of progesterone further increases Fos expression within a few hours in female rat brain. In order to determine if neurons that respond to progesterone with increased Fos expression also contain progestin receptors, we used a double-label immunofluorescent technique to label both progestin receptors and Fos protein following progesterone or vehicle treatment of estradiol-primed female rats. As shown previously, progesterone treatment increased Fos expression in progestin receptor-containing regions, such as the ventromedial nucleus of the hypothalamus and the medial preoptic area. In addition, progesterone treatment induced a statistically-significant increase in Fos-immunoreactivity within progestin receptor-containing cells in the medial preoptic area and the ventromedial nucleus of the hypothalamus, but not in the arcuate nucleus. Therefore, many but not all of the neurons that respond to progesterone with increased Fos expression also contain progestin receptor-immunoreactivity. The progesterone-induced Fos expression within progestin receptor-containing neurons may or may not be associated with the effects of progesterone on sexual or other reproductive behaviors, as it remains to be tested. However, the Fos expression provides a useful marker to aid in identification of neurons that respond to a behaviorally-relevant dose of progesterone.
Url:
DOI: 10.1016/S0006-8993(96)01190-0
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000D50
- to stream Istex, to step Curation: 000D50
- to stream Istex, to step Checkpoint: 000B38
- to stream Main, to step Merge: 001045
- to stream Main, to step Curation: 000F83
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Progesterone treatment increases Fos-immunoreactivity within some progestin receptor-containing neurons in localized regions of female rat forebrain</title><author><name sortKey="Auger, Anthony P" sort="Auger, Anthony P" uniqKey="Auger A" first="Anthony P" last="Auger">Anthony P. Auger</name></author><author><name sortKey="Blaustein, Jeffrey D" sort="Blaustein, Jeffrey D" uniqKey="Blaustein J" first="Jeffrey D" last="Blaustein">Jeffrey D. Blaustein</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2CA44E73C95AD9E7C63261D02CB045378C7D5E16</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1016/S0006-8993(96)01190-0</idno><idno type="url">https://api.istex.fr/document/2CA44E73C95AD9E7C63261D02CB045378C7D5E16/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000D50</idno><idno type="wicri:Area/Istex/Curation">000D50</idno><idno type="wicri:Area/Istex/Checkpoint">000B38</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000B38</idno><idno type="wicri:doubleKey">0006-8993:1997:Auger A:progesterone:treatment:increases</idno><idno type="wicri:Area/Main/Merge">001045</idno><idno type="wicri:Area/Main/Curation">000F83</idno><idno type="wicri:Area/Main/Exploration">000F83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Progesterone treatment increases Fos-immunoreactivity within some progestin receptor-containing neurons in localized regions of female rat forebrain</title><author><name sortKey="Auger, Anthony P" sort="Auger, Anthony P" uniqKey="Auger A" first="Anthony P" last="Auger">Anthony P. Auger</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroscience and Behavior Program and Psychology Department, Tobin Hall, Box 37710, University of Massachusetts, Amherst, MA 01003-7710</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Amherst (Massachusetts)</settlement></placeName><orgName type="university">Université du Massachusetts</orgName></affiliation></author><author><name sortKey="Blaustein, Jeffrey D" sort="Blaustein, Jeffrey D" uniqKey="Blaustein J" first="Jeffrey D" last="Blaustein">Jeffrey D. Blaustein</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroscience and Behavior Program and Psychology Department, Tobin Hall, Box 37710, University of Massachusetts, Amherst, MA 01003-7710</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Amherst (Massachusetts)</settlement></placeName><orgName type="university">Université du Massachusetts</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">746</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="164">164</biblScope><biblScope unit="page" to="170">170</biblScope></imprint><idno type="ISSN">0006-8993</idno></series><idno type="istex">2CA44E73C95AD9E7C63261D02CB045378C7D5E16</idno><idno type="DOI">10.1016/S0006-8993(96)01190-0</idno><idno type="PII">S0006-8993(96)01190-0</idno><idno type="ArticleID">13038</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Hypothalamus</term><term>Immediate early gene</term><term>Preoptic area</term><term>Progesterone</term><term>Progestin receptor</term><term>c-fos</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In female rats, the sequential release of estradiol and progesterone from the ovaries is required for the expression of sexual behavior during the estrous cycle. Many of the neuronal effects of estradiol and progesterone involve estrogen and progestin receptors. Treatment with a behaviorally-effective dose of estradiol increases Fos expression, suggestive of neuronal response, and subsequent treatment with a behaviorally-effective dose of progesterone further increases Fos expression within a few hours in female rat brain. In order to determine if neurons that respond to progesterone with increased Fos expression also contain progestin receptors, we used a double-label immunofluorescent technique to label both progestin receptors and Fos protein following progesterone or vehicle treatment of estradiol-primed female rats. As shown previously, progesterone treatment increased Fos expression in progestin receptor-containing regions, such as the ventromedial nucleus of the hypothalamus and the medial preoptic area. In addition, progesterone treatment induced a statistically-significant increase in Fos-immunoreactivity within progestin receptor-containing cells in the medial preoptic area and the ventromedial nucleus of the hypothalamus, but not in the arcuate nucleus. Therefore, many but not all of the neurons that respond to progesterone with increased Fos expression also contain progestin receptor-immunoreactivity. The progesterone-induced Fos expression within progestin receptor-containing neurons may or may not be associated with the effects of progesterone on sexual or other reproductive behaviors, as it remains to be tested. However, the Fos expression provides a useful marker to aid in identification of neurons that respond to a behaviorally-relevant dose of progesterone.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region><settlement><li>Amherst (Massachusetts)</li></settlement><orgName><li>Université du Massachusetts</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Auger, Anthony P" sort="Auger, Anthony P" uniqKey="Auger A" first="Anthony P" last="Auger">Anthony P. Auger</name></region><name sortKey="Blaustein, Jeffrey D" sort="Blaustein, Jeffrey D" uniqKey="Blaustein J" first="Jeffrey D" last="Blaustein">Jeffrey D. Blaustein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Eau/explor/LotaV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F83 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F83 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Eau
|area= LotaV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:2CA44E73C95AD9E7C63261D02CB045378C7D5E16
|texte= Progesterone treatment increases Fos-immunoreactivity within some progestin receptor-containing neurons in localized regions of female rat forebrain
}}
| This area was generated with Dilib version V0.6.39. |  |